Can CEA Levels Be High Without Cancer?

How accurate is a CEA blood test?

Sensitivity of CEA ranged from 17.4 % to 100 %, specificity ranged from 66.1 % to 98.4 %, positive predictive value ranged from 45.8 % to 95.2% and negative predictive value ranged from 74.5 % to 100 %..

Does CEA increase with age?

Background. Carcinoembryonic antigen (CEA), a serological marker of malignant tumors, demonstrates a modest increase under nonmalignant conditions such as aging and smoking. Also, recent study results suggested that serum CEA levels may be related to insulin resistance or low-grade inflammation.

What is a high level of CA 19 9?

Here is what your results may mean: If your CA 19-9 is less than 37 U/mL, you may not have cancer. If your CA 19-9 is above 37 U/mL, you may have cancer of the pancreas, liver, gallbladder, lung, colon, or stomach.

How long does it take for CEA blood test results?

It may also be present in people with cancer of the pancreas, breast, ovary, or lung. Results are usually available in 1 to 3 days.

Is CEA a reliable tumor marker?

Doctors don’t use the CEA test to make a first-time diagnosis of cancer. This test isn’t an accurate way to screen for it because many other diseases can cause the levels of this protein to rise. And some people with cancer don’t have high CEA levels.

Can CEA be false positive?

Conclusions: False positive CEAs in the 5-15 range are relatively common. Confirmation of CEA elevation in this range prior to initiating imaging studies may be appropriate. False positive CEAs above 15 are rare.

Can alcohol increase CEA levels?

The mean plasma carcinoembryonic antigen (CEA) level was found to be significantly increased in 66 patients with alcoholic liver disease (4.4μg/1) compared with the mean CEA level in 164 healthy blood donors (1.6μg/1, p < 0.001).

Can CEA be high without cancer?

Can CEA be high without having cancer? Yes, elevations in CEA and CA 19-9 levels may occur in patients without cancer.

Can stress cause tumor markers to rise?

The study, which followed 96 patients with chronic lymphocytic leukemia (CLL), found that those who felt more stress and anxiety about about their condition also had a higher volume of cancer cells in their blood and higher blood levels of markers for advanced disease.

Can tumor markers go up and down?

Tumor markers are most often used to track how a patient’s cancer responds to treatment. If the level is going down, the treatment is working. If it goes up, the cancer may be growing.

How often should CEA test be done?

CEA test. This is a blood test that detects the levels of CEA protein. High levels of CEA may indicate that a cancer has spread to other parts of the body. CEA testing is recommended every three to six months for five years.

Is it normal for CEA levels to fluctuate?

Serum CEA levels fluctuate over time in healthy individuals, and the intraindividual variation has been reported to be about 30% [19].

What is considered a high CEA level?

Levels of CEA higher than 20 ng/mL are considered very high. If you have CEA levels this high and you also have symptoms of cancer, it strongly suggests the cancer has not been removed successfully after treatment.

What does a CEA blood test show?

The carcinoembryonic antigen (CEA) test measures the level of CEA in the blood. CEA is a protein normally found in the tissue of a developing baby in the womb. The blood level of this protein disappears or becomes very low after birth. In adults, an abnormal level of CEA may be a sign of cancer.

What happens if CEA is high?

A high level of CEA can be a sign of certain types of cancers. These include cancers of the colon and rectum, prostate, ovary, lung, thyroid, or liver. High CEA levels may also be a sign of some noncancerous conditions, such as cirrhosis, noncancerous breast disease, and emphysema.

What causes tumor markers to rise?

Sometimes, noncancerous conditions can cause the levels of certain tumor markers to increase. In addition, not everyone with a particular type of cancer will have a higher level of a tumor marker associated with that cancer.

What are common tumor markers?

Types of Tumor MarkersProstate-specific antigen (PSA)Prostatic acid phosphatase (PAP)CA 125.Carcinoembryonic antigen (CEA)Alpha-fetoprotein (AFP)Human chorionic gonadotropin (HCG)CA 19-9.

Do you have to fast for a CEA blood test?

This CEA Blood Test measures the protein in the blood called carcinoembryonic antigen (CEA). This protein can be found on some cancer cell types. Preparation: No fasting required.

What is a CA 125 test?

What is a CA-125 blood test? This test measures the amount of a protein called CA-125 (cancer antigen 125) in the blood. CA-125 levels are high in many women with ovarian cancer. The ovaries are a pair of female reproductive glands that store ova (eggs) and make female hormones.

What can cause a false positive CEA?

Elevated serum CEA is not highly specific for colon cancer recurrence, while various other gastrointestinal disorders such as pancreatitis, peptic ulcer disease, biliary tract abnormalities (benign or malignant) and liver disorders may contribute to increased serum CEA and false-positive results [2].